Author

H. Safi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Levine· 2 shared D. Alland· 2 shared A. Baumbach· 1 shared A. Mathur· 1 shared A. Ramasamy· 1 shared A. Sakellarios· 1 shared A. Thomas· 1 shared C. V. Bourantas· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

C. Levine

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Author profile →

3 papers

Recent·Most cited

Comparison of shear stress patterns by the established and advanced reconstruction method incorporating side branches to predict plaque progression

A. Ramasamy, L. Räber, I. h. Tanboga, H. Safi, M. Hadjiandreou, A. Sakellarios, P. H. Kitslaar, J. Dijkstra, F. G. Biccire, T. Crake, L. K. Michalis, D. Fotiadis, S. Windecker, Y.-J. Zhang, A. Mathur, , C. V. Bourantas

This study compares wall shear stress (WSS) metrics from complete vessel reconstruction (CVR) and single vessel reconstruction (SVR) methods to assess their ability to predict atherosclerotic disease progression.

bioRxiv · Apr 5, 2023 · PreprintBioengineering

Origin and dynamics of Mycobacterium tuberculosis subpopulations that predictably generate drug tolerance and resistance

D. Alland, J. Sebastian, A. Thomas, C. Levine, R. Shrestha, S. Levy, H. Safi, S. R. Pentakota, P. Kumar

This paper identifies drug-tolerant subpopulations in Mycobacterium tuberculosis using a multi-transwell system and barcoding, showing their role in generating resistance.

bioRxiv · Oct 5, 2022Microbiology

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

H. Safi, P. Gopal, S. Lingaraju, S. Ma, C. Levine, V. Dartois, M. Yee, L. Li, L. Blanc, H.-P. H. Liang, S. Husain, M. Hoque, P. Soteropoulos, T. Rustad, D. Sherman, , D. Alland

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.

bioRxiv · Jul 30, 2019Microbiology