Hyun O. Lee

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

The paper identifies a biochemical mechanism by which the MpARF1 transcription factor activates gene expression through subnuclear clustering and Mediator complex recruitment, revealing an evolutionary innovation in auxin response.

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

The paper shows that protein-free mRNA induces stress granules via two G3BP1/2-dependent mechanisms, one involving PKR and eIF2 phosphorylation, and another independent of PKR and phospho-eIF2.

BrainRBPedia is a database of 1072 RNA-binding proteins linked to neurodevelopmental disorders, with a machine learning model prioritizing RBPs for autism and intellectual disability.

This study shows that Rad52 proteins in yeast form liquid droplets that facilitate DNA repair by tethering damaged DNA to microtubules.