Author

I. A. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Bioengineering· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

E. Janzen· 2 shared Y. Shen· 2 shared A. D. Pressman· 1 shared A. Mukherjee· 1 shared B. Obermayer· 1 shared B. Xu· 1 shared C. Blanco· 1 shared D. A. Boas· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

E. Janzen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Measuring Capillary Flow Dynamics using Interlaced Two-Photon Volumetric Scanning

J. Giblin, S.-W. Park, J. Jiang, K. Kilic, S. Kura, D. A. Boas, I. A. Chen

The paper introduces a custom two-photon system with Bessel beams and a novel scan pattern to measure capillary flow dynamics in 3D with high temporal resolution and fluorescent specificity.

bioRxiv · Sep 12, 2022Bioengineering

A genetically engineered phage-based nanomaterial for detecting bacteria with magnetic resonance imaging

R. E. Borg, H. F. Ozbakir, B. Xu, E. Li, X. Fang, H. PENG, I. A. Chen, A. Mukherjee

This paper develops a genetically engineered phage-based nanomaterial for MRI detection of specific bacteria, demonstrating its ability to distinguish target strains from non-target bacteria and mammalian cells in vivo.

bioRxiv · Jun 7, 2022 · PreprintBioengineering

A kinetic error filtering mechanism for enzyme-free copying of nucleic acid sequences

T. Göppel, B. Obermayer, I. A. Chen, U. Gerland

This paper introduces a kinetic error filtering mechanism to improve the accuracy of enzyme-free nucleic acid copying, showing it can produce exact 50mer sequences under cyclic environmental conditions.

bioRxiv · Aug 6, 2021 · PreprintEvolutionary Biology

Error minimization and specificity could emerge in a genetic code as by-products ofprebiotic evolution

E. Janzen, Y. Shen, Z. Liu, C. Blanco, I. A. Chen

This study shows that error minimization and specificity in the genetic code could emerge as by-products of prebiotic evolution through ribozyme co-option.

bioRxiv · May 14, 2021 · PreprintBiochemistry

Kinetic sequencing (k-Seq) as a massively parallel assay for ribozyme kinetics: utility and critical parameters

Y. Shen, A. D. Pressman, E. Janzen, I. A. Chen

The paper evaluates the k-Seq method for measuring ribozyme kinetics, identifying factors affecting accuracy and proposing guidelines to improve data quality.

bioRxiv · Dec 2, 2020Biochemistry