E. Li

SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.

This study investigates the role of the SLO2.1/NALCN complex in regulating mouse myometrial smooth muscle cell membrane potential across pregnancy, finding its activity decreases as pregnancy progresses.

An in-depth analysis and exploreation with focus on the biofilm in Staphylococcus aureus

This study analyzes RNA sequencing data on Staphylococcus aureus biofilm formation using machine learning and co-expression analysis to identify functional modules and novel protein interactions, and develops a database for storing and analyzing the data.

CTHRC1+ Fibroblasts and SPP1+ Macrophages Synergistically Contribute to Pro-Tumorigenic Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

This study identifies SPP1+ macrophages and CTHRC1+ fibroblasts as synergistic contributors to an immunosuppressive tumor microenvironment in PDAC, linked to poor prognosis.

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

This study uses single nucleus RNA-Seq to show increased adipogenesis and IGF-1R pathway alterations in TED orbital fat, suggesting linsitinib as a potential therapeutic.

A Novel Magnetic Field Device: Effects of Magnetic Fields on Planktonic Yeasts and Fungal Mats

This study develops a 3D-printed magnetic field exposure device to investigate the effects of static magnetic fields on yeast and fungal growth, finding that magnetic fields slow 2D yeast mat expansion but not liquid growth.

Toxin-glycolipid interactions measured by imaging surface plasmon resonance on artificial membranes predicts diffusion behavior and lipid dependence of binding to cells

The paper uses imaging surface plasmon resonance and fluorescence correlation spectroscopy to study toxin-glycolipid interactions and their lipid dependencies on artificial and cellular membranes.

The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

ESPressoscope: a small and powerful platform for in situ microscopy

The paper introduces ESPressoscope, a low-cost, portable digital microscope platform for in situ imaging, demonstrating its versatility and accessibility for various biological and ecological applications.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Engineering ligand stabilized aquaporin reporters for magnetic resonance imaging

This paper introduces LSAqp1, a genetically encoded MRI reporter that enables drug-gated, background-free, and multiplex imaging of gene expression in living organisms.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Control of lipolysis by a population of oxytocinergic sympathetic neurons

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

A genetically engineered phage-based nanomaterial for detecting bacteria with magnetic resonance imaging

This paper develops a genetically engineered phage-based nanomaterial for MRI detection of specific bacteria, demonstrating its ability to distinguish target strains from non-target bacteria and mammalian cells in vivo.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

A wheat resistosome defines common principles of immune receptor channels

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

STK25 inhibits PKA signaling by phosphorylating PRKAR1A

This study identifies STK25 as a kinase that phosphorylates PRKAR1A, inhibiting PKA signaling and reducing myocardial contractility in response to beta adrenergic stimulation.

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response by regulating the EGF/Rad51 axis

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death

Relationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges

The paper analyzes bacterial phylotype and specialized metabolite production in two freshwater sponges to show species-level variation in SM production and the need for detailed analysis.

A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice

Squid: Simplifying Quantitative Imaging Platform Development and Deployment

Squid provides an affordable, open-source imaging platform with modular hardware and software for deploying advanced microscopy techniques in research and low-resource settings.

Rapid evolution of bacterial mutualism in the plant rhizosphere

This study shows that a plant-antagonistic bacterium can evolve into a mutualist in the Arabidopsis rhizosphere within six months through genetic changes enhancing competitiveness and plant signaling activation.

Experimental evolution-driven identification of Arabidopsis rhizosphere competence genes in Pseudomonas protegens

This study uses experimental evolution to identify 35 mutations in 28 genes that enhance Pseudomonas protegens' ability to colonize the Arabidopsis thaliana rhizosphere.

Knockdown of LC3 increases mitochondria-to-micronucleus transition

The paper shows that knocking down LC3 increases micronuclei by promoting mitochondria-to-micronuclei transition during nuclear development.

Mitochondria fragment and reassemble to initiate the formation and development of the nucleus

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

Diversity of carbapenem-resistant Acinetobacter baumannii and bacteriophage-mediated spread of the Oxa23 carbapenemase

This study characterizes carbapenem-resistant Acinetobacter baumannii in Egypt, revealing genetic diversity and bacteriophage-mediated spread of the oxa23 carbapenemase.

Bacterial evolution in high osmolarity environments

This study evolves Escherichia coli in high osmolarity environments and finds that adaptation strategies vary by osmolyte, with specific mutations improving fitness in certain conditions.