I. Jayasinghe

Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion microscopy

The paper evaluates 14 fluorescent dye esters for their ability to label human sub-cellular compartments using expansion microscopy, finding differential staining patterns and specificity influenced by dye properties and experimental conditions.

Geometry-preserving Expansion Microscopy microplates enable high fidelity nanoscale distortion mapping

This paper introduces a microplate system for expansion microscopy that preserves gel geometry and enables distortion mapping in HeLa cells.

Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease

The paper correlates cardiac calcium sparks with RyR clustering patterns using super-resolution microscopy in healthy and failing rat ventricular myocytes, revealing a link between spark properties and RyR organization.

Cysteine post-translational modifications regulate protein interactions of caveolin-3

This study identifies cysteine post-translational modifications in caveolin-3 that regulate its protein interactions and structural properties in muscle cells.

Expansion microscopy reveals subdomains in C. elegans germ granules

This study uses expansion microscopy to reveal subdomains within C. elegans P granules and their relationship to other germ granules.

3D visualisation of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads

This study uses 3D visualization to examine RyR cluster structure and JPH2 sub-domains in cardiac dyads, revealing fragmentation in disease states.

A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types

The paper describes a correlative imaging protocol to visualize calcium signals and ryanodine receptors at nanoscale resolution in primary cells.

Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes

The paper investigates peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes, finding that they label non-specific structures in cardiomyocytes.

Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time

This paper introduces sandSTORM, a STORM variant using nanodiamonds for faster, less damaging super-resolution imaging with unlimited observation time.