E. White

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

CTAT-LR-fusion: accurate fusion transcript identification from long and short read isoform sequencing at bulk or single cell resolution

CTAT-LR-fusion detects fusion transcripts from long and short read RNA-seq data, improving accuracy in bulk and single cell transcriptomes.

Thermal Tolerance Plasticity and Dynamics of Thermal Tolerance in Eublepharis macularius: Implications for Future Climate-Driven Heat Stress

This study examines thermal tolerance and plasticity in the crepuscular gecko Eublepharis macularius, finding that plasticity is independent of basal tolerance, peaks after 6 hours, and is negatively related to body mass.

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

Transferability of ecological forecasting models to novel biotic conditions in a long-term experimental study

This study evaluates how ecological forecasting models perform under novel biotic conditions using a long-term desert rodent experiment, showing reduced accuracy and increased uncertainty when models are transferred to new conditions.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

On the role of melanistic coloration on thermoregulation in the crepuscular gecko Eublepharis macularius

This study investigates whether melanistic coloration in crepuscular geckos affects thermoregulation, finding no significant relationship between melanistic coloration and body temperature changes.

Genetic basis of aposematic coloration in a mimetic radiation of poison frogs

This study identifies genes underlying Mullerian mimicry in poison frogs and shows that mimicry evolved through independent selective sweeps on color and pattern loci.

Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease

The paper correlates cardiac calcium sparks with RyR clustering patterns using super-resolution microscopy in healthy and failing rat ventricular myocytes, revealing a link between spark properties and RyR organization.

Capturing long-tailed individual tree diversity using an airborne multi-temporal hierarchical model

The paper develops a multi-temporal hierarchical model to improve rare tree species classification in airborne imagery, achieving 75% accuracy for 14 species and generating species maps for over 670,000 trees.

Jointly Modeling Species Niche and Phylogenetic Models in a Bayesian Hierarchical Framework

This paper introduces a Bayesian hierarchical model that integrates phylogenetic relationships with environmental niche modeling to improve predictions of species distributions and niche parameters.

Skin-resident immune cells engulf axonal debris in adult epidermis

The paper identifies Langerhans cells as the primary phagocytes clearing axon debris in adult zebrafish skin following Wallerian degeneration.

A baseline for the genetic stock identification of Atlantic herring, Clupea harengus, in ICES Divisions 6.a, 7.b-c

The paper develops a genetic assignment method using SNPs to identify Atlantic herring populations in ICES Divisions 6.a, 7.b-c with high accuracy.

Sizing up spotted lanternfly nymphs for instar determination and growth allometry

This study measures body mass and length of spotted lanternfly nymphs across instars and finds distinct clusters for first three instars, variable allometry, and stage-specific adhesion traits.

3D visualisation of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads

This study uses 3D visualization to examine RyR cluster structure and JPH2 sub-domains in cardiac dyads, revealing fragmentation in disease states.

Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat

This paper develops a serum-free medium for bovine satellite cells, enabling long-term expansion without losing myogenicity.

GDF8 Contributes to the Adverse Effects of Liver Injury on Skeletal Muscle Homeostasis and Regeneration

This study identifies GDF8 as a mediator of liver-muscle crosstalk that contributes to muscle atrophy in liver disease and shows that targeting GDF8 can reverse these effects.

Individual tree-crown detection in RGB imagery using semi-supervised deep learning neural networks

This paper develops a semi-supervised deep learning method to detect tree crowns in RGB imagery using unsupervised LIDAR data and a small number of hand-annotated images, achieving accurate predictions in natural landscapes.

Comparison of changes in electrical activity, in isolated and in vivo hearts, induced by voluntary exercise in female rats

This study examines how voluntary exercise affects electrical activity in isolated and in vivo rat hearts, finding that intrinsic cellular changes persist despite extrinsic influences.

The spore of the beans: Spatially explicit models predict coffee rust spread in fragmented landscapes

The paper models coffee rust spread in fragmented landscapes, finding that coffee plant clustering is the main driver of rust transmission, with deforestation exacerbating outbreaks in clustered landscapes.

A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types

The paper describes a correlative imaging protocol to visualize calcium signals and ryanodine receptors at nanoscale resolution in primary cells.

NEON Crowns: a remote sensing derived dataset of 100 million individual tree crowns

The paper introduces a dataset of 100 million individual tree crowns derived from remote sensing and deep learning, enabling large-scale forest analysis.

Estimating individual level plant traits at scale

This paper develops a method to estimate individual tree traits at scale using remote sensing data, achieving moderate accuracy for several traits and demonstrating improved performance over pixel-level predictions.

The Broken Window: An algorithm for quantifying and characterizing misleading trajectories in ecological processes

The paper introduces the broken_window algorithm to assess the reliability of short-term ecological trends by resampling long-term data and evaluating the likelihood of misleading trajectories.

Matching the forecast horizon with the relevant spatial and temporal processes and data sources

The paper shows that ecological forecasts should use different approaches depending on the forecast horizon, with time-series for short-term and space-for-time for long-term.

No general relationship between mass and temperature in endothermic species

The paper analyzes the relationship between temperature and body mass in 952 bird and mammal species, finding that temperature explains little variation in mass for most species.

The prevalence and impact of transient species in ecological communities

This study quantifies the prevalence and impact of transient species across ecosystems and finds they affect ecological patterns and should be considered in analyses.