Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis
D. Williams, M. Mahmoud, R. Liu, A. Andueza, S. Kumar, D.-W. Kang, J. Zhang, I. Tamargo, N. Villa-Roel, K.-I. Baek, H. Lee, Y. An, L. Zhang, E. W. Tate, P. Bagchi, , H. Jo
This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.
eLife · Jan 11, 2022Peer-reviewedCell Biology