J. A. MacDonald

This study examines the sex-specific effects of SMTNL1 deletion on metabolic phenotype in aged mice, finding increased adiposity and altered energy metabolism in females.

This study uses molecular dynamics simulations to show that ATP binding induces conformational changes in NLRP3, while ADP binding stabilizes its structure.

This study shows DAPK3 regulates actin cytoskeleton in cerebral arterioles, not Ca2+ sensitization, and its inhibition affects myogenic reactivity in rat and human vessels.

This study shows that DAPK3 inhibition impairs intestinal epithelial wound healing and colitis resolution in mice by affecting YAP signaling.

This study investigates the CaM-binding properties of AQP4's N- and C-terminal domains, revealing a unique binding mode that may regulate vesicular trafficking.

This study shows that SMTNL1 knockout mice exhibit enhanced diastolic dysfunction but preserved systolic function after acute pressure overload, resembling HFpEF pathophysiology.