Author

J. Abendroth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

B. Staker· 2 shared I. Q. Phan· 2 shared J. E. Milanes· 2 shared M. Bolejack· 2 shared T. E. Edwards· 2 shared A. B. Suryawanshi· 1 shared A. Deshmukh· 1 shared A. Gustchina· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. Staker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

J. E. Milanes, V. C. Yan, C.-D. Pham, F. L. Muller, S. Kwain, K. C. Rees, B. N. Dominy, D. C. Whitehead, S. W. Millward, M. Bolejack, J. Abendroth, I. Q. Phan, B. Staker, E. A. Moseman, X. Zhang, , J. Morris

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

A. Maker, M. Bolejack, L. Schecterson, B. Hammerson, J. Abendroth, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

bioRxiv · Mar 21, 2022Biochemistry

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

p. kesari, A. Deshmukh, N. Pahelkar, A. B. Suryawanshi, I. Rathore, V. Mishra, J. H. Dupuis, H. Xiao, A. Gustchina, J. Abendroth, M. Labaied, R. Y. Yada, A. Wlodawer, T. E. Edwards, D. D. Lorimer, P. Bhaumik

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

bioRxiv · Sep 24, 2021Biophysics

Enzymatic and structural characterization of the Naegleria fowleri glucokinase

J. E. Milanes, J. Suryadi, J. Abendroth, W. C. Van Voorhis, K. F. Barrett, D. M. Dranow, I. Q. Phan, S. L. Patrick, S. D. Rozema, M. M. Khalifa, J. E. Golden, J. C. Morris

This study characterizes the enzymatic properties and structure of Naegleria fowleri glucokinase, identifying potential inhibitors for therapeutic development against the parasite.

bioRxiv · Nov 14, 2018Biochemistry