Author

B. Staker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Maker· 2 shared B. M. Gumbiner· 2 shared J. Abendroth· 2 shared M. Bolejack· 2 shared P. J. Myler· 2 shared T. E. Edwards· 2 shared A. Jebet· 1 shared A. V. Priest· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. Maker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

J. E. Milanes, V. C. Yan, C.-D. Pham, F. L. Muller, S. Kwain, K. C. Rees, B. N. Dominy, D. C. Whitehead, S. W. Millward, M. Bolejack, J. Abendroth, I. Q. Phan, B. Staker, E. A. Moseman, X. Zhang, , J. Morris

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

A. Maker, M. Bolejack, L. Schecterson, B. Hammerson, J. Abendroth, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

bioRxiv · Mar 21, 2022Biochemistry

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

B. Xie, A. Maker, A. V. Priest, D. M. Dranow, J. N. Phan, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner, S. Sivasankar

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

bioRxiv · Mar 6, 2022Biophysics