Author

B. M. Gumbiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Maker· 2 shared B. Staker· 2 shared B. Xie· 2 shared L. Schecterson· 2 shared P. J. Myler· 2 shared S. Sivasankar· 2 shared T. E. Edwards· 2 shared A. J. H. Cabrera· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Maker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiophysicsbioRxivJul 4, 2023

Strengthening E-cadherin adhesion via antibody mediated binding stabilization.

B. Xie, S. Xu, L. Schecterson…·S. Sivasankar

This study identifies how the monoclonal antibody 66E8 stabilizes E-cadherin adhesion by stabilizing the strand-swap dimer conformation through electrostatic interactions.

DOI 10.1016/j.str.2023.11.002

mechanistic / dynamical modelexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMar 21, 2022

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

A. Maker, M. Bolejack, L. Schecterson…·B. M. Gumbiner

The paper uses Cryo-EM and X-ray crystallography to reveal how activating antibodies regulate E-cadherin dimer states through structural changes and interactions.

DOI 10.1093/pnasnexus/pgac163

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivMar 6, 2022

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

B. Xie, A. Maker, A. V. Priest…·S. Sivasankar

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

DOI 10.1073/pnas.2204473119

humanstructural biology

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 10, 2021

The roles of distinct Ca2+ signaling mediated by Piezo and inositol triphosphate receptor (IP3R) in the remodeling of E-cadherin during cell dissemination

A. J. H. Cabrera, B. M. Gumbiner, Y. V. Kwon

This study shows that E-cadherin remodeling during cell dissemination in Drosophila is controlled by two distinct Ca2+ signaling pathways mediated by IP3R and Piezo.

DOI 10.1101/2021.11.10.467957

Drosophilaexperimental assay

𝕏 PostBluesky