J. Almeida-Santos

This study investigates how TCR signaling controls CD4 T-cell differentiation and Treg development after SARS-CoV-2 spike protein immunization using temporal profiling techniques.

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

This study identifies hyperactivation and paralysis of CD4+ T-cells in severe COVID-19 through single-cell analysis, revealing their role in cytokine release syndrome and viral entry.

This study shows that interrupting thymic activity in adult mice reduces Treg cells and enhances tumor immunotherapy responses.

This study shows that a weak Foxp3 hypomorph allele enhances anti-tumor immunity in mice, reducing tumor growth and improving response to immunotherapy.