M. Ono

Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

The paper identifies genetic variations in emm89 Streptococcus pyogenes associated with invasive infections using genome-wide association studies and validates one mutation's effect on bacterial growth.

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent anti-PD-L1- and anti-NKG2A-based adjuvant immunotherapy

This study combines ATR inhibition with radiotherapy and immune checkpoint blockade to enhance antitumour immunity in HNSCC preclinical models.

Feeding Behavior Modifies the Circadian Variation in RR and QT intervals by Distinct Mechanisms in Mice

This study shows feeding behavior affects RR and QT interval rhythms in mice through distinct mechanisms, with RR intervals linked to autonomic signaling and QT intervals to core body temperature.

HIV-Tocky system to visualize proviral expression dynamics

The paper introduces HIV-Tocky, a reporter system using a fluorescent Timer protein to visualize HIV-1 provirus expression dynamics and identifies two latent subsets of proviruses.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation

This study investigates how TCR signaling controls CD4 T-cell differentiation and Treg development after SARS-CoV-2 spike protein immunization using temporal profiling techniques.

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control

This study shows that social isolation in mice increases resistance to bacterial sepsis, linked to changes in gene expression and cytokine production, which can be reversed by artificial nesting.

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis

This study identifies hyperactivation and paralysis of CD4+ T-cells in severe COVID-19 through single-cell analysis, revealing their role in cytokine release syndrome and viral entry.

Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

The paper identifies differential Nr4a1 and Nr4a3 expression as markers distinguishing tonic from activating TCR signalling in T cells.

Immuno-moodulin: a new anxiogenic factor produced by autoimmune-prone T cells

The paper identifies Immuno-moodulin, a novel anxiogenic factor produced by autoimmune-prone T cells, and shows its role in modulating anxiety behavior in mice and its presence in patients with obsessive compulsive disorders.

Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA

This paper investigates the role of PfbA in Streptococcus pneumoniae pathogenesis, finding that it inhibits phagocytosis and modulates host inflammation, with differential effects in pneumonia and sepsis models.

A Timer for analyzing temporally dynamic changes in transcription during differentiation in vivo

The paper introduces Tocky, a tool that reveals temporal dynamics of cellular differentiation in vivo by using a fluorescent timer protein and algorithms to track molecular processes.

Elucidating the activation mechanisms for bifurcation of regulatory and effector T cell fates by multidimensional single cell analysis

This study uses single-cell RNA-seq and multidimensional analysis to show how TCR signals control the activation and differentiation of regulatory and effector T cells.

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme

This study uses a Foxp3 Timer system to analyze Foxp3 transcription dynamics in Treg cells during immune responses, showing that persistent Foxp3 transcription drives effector Treg programs and can be modulated by immunotherapy.