J. Augenstreich

This paper introduces two automated methods for quantifying bacterial burden in macrophages using confocal microscopy, validated with Salmonella and Mycobacterium models.

This study investigates LC3 recruitment to Mtb-containing vacuoles in macrophages, revealing its variability and lack of correlation with autophagosome maturation or membrane repair.

This study shows that phthiocerol dimycocerosates (DIM) from Mycobacterium tuberculosis increase membrane activity of both bacterial effectors and host receptors, aiding immune evasion.

This study identifies the conical shape of DIM lipids as a key factor in promoting Mycobacterium tuberculosis infection of macrophages through phagocytosis.