Author

C. Guilhot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

C. Astarie-Dequeker· 2 shared C. Chalut· 2 shared E. Haanappel· 2 shared J. Augenstreich· 2 shared S. Mazeres· 2 shared A. Milon· 1 shared A. Pawlik· 1 shared A. Sanchez Dafun· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

C. Astarie-Dequeker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

S. A. Leon Icaza, S. Bagayoko, R. VERGE, N. Iakobachvili, C. Ferrand, T. Aydogan, C. Bernard, A. Sanchez Dafun, M. Murris-Espin, J. Mazieres, P. J. Bordignon, S. Mazeres, P. Bernes Lasserre, V. Rame, J.-M. Lagarde, , C. Cougoule

This study uses airway organoids to investigate M. abscessus infection in CF patients, showing antioxidant pathways can inhibit bacterial growth and enhance antibiotic efficacy.

bioRxiv · Jan 3, 2022 · PreprintCell Biology

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

T. Laval, L. Pedro-Cos, W. Malaga, L. Guenin-Mace, A. Pawlik, V. Mayau, H. Yahia-Cherbal, W. Frigui, J. Bertrand-Michel, C. Guilhot, C. Demangel

This study shows that Mycobacterium tuberculosis uses host-derived arachidonic acid, a polyunsaturated fatty acid, for growth and immune evasion.

bioRxiv · Jul 8, 2021Immunology

Phthiocerol dimycocerosates from Mycobacterium tuberculosis increase the membrane activity of bacterial effectors and host receptors

J. Augenstreich, E. Haanappel, F. Sayes, R. Simeone, V. Guillet, S. Mazeres, C. Chalut, L. Mourey, R. Brosch, C. Guilhot, C. Astarie-Dequeker

This study shows that phthiocerol dimycocerosates (DIM) from Mycobacterium tuberculosis increase membrane activity of both bacterial effectors and host receptors, aiding immune evasion.

bioRxiv · May 13, 2020Microbiology

The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages

J. Augenstreich, E. Haanappel, G. Ferre, G. Czaplicki, F. Jolibois, N. Destainville, C. Guilhot, A. Milon, C. Astarie-Dequeker, M. Chavent

This study identifies the conical shape of DIM lipids as a key factor in promoting Mycobacterium tuberculosis infection of macrophages through phagocytosis.

bioRxiv · Jun 3, 2019Biophysics