ImmunologybioRxiv
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
J. B. Wong, S. L. Hewitt, L. M. Heltemes-Harris…·J. A. Skok
This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.
DOI 10.1038/s41467-019-12824-z