K. Johnson

A reaction norm for flowering time plasticity reveals physiological footprints of maize adaptation

This paper models flowering time plasticity in maize using a physiological reaction norm, revealing genotype-specific differences in environmental perception and adaptation strategies.

Enhancing reproducibility and decentralization in single cell research with biocytometry

This study evaluates biocytometry's performance in a decentralized setting, showing its ability to accurately count rare cells across multiple labs with minimal training.

Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis

The paper shows that telomerase inhibitors TMPyP4 and PDS also inhibit telomeric C-strand synthesis by stabilizing DNA structures and blocking CST-PP binding.

Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother's milk

This study links the infant gut microbiome and resistome to bacterial strains in mother's milk using metagenomic samples from mother-infant pairs.

Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants

The paper identifies a conserved mechanism regulating class-B ARF protein levels in land plants through comparative mutant analysis in maize and moss.

Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome

This study evaluates combination therapies for Dravet Syndrome using a mouse model, finding that triple-drug regimens enhance seizure control through potential drug interactions.

Hybrid Mimulus flowers attract a new pollinator

The paper shows hybrid Mimulus flowers attract bumblebees due to novel floral traits and the YUP locus, suggesting hybridization may drive pollinator shifts and speciation.

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

This study identifies multiple beta cell-independent mechanisms causing hypoglycemia in Timothy syndrome using a novel mouse model.

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation

The paper uses mouse models to map sepsis' effects across organs, identifying cytokine circuits and PLA2G5's role in hemolysis and organ failure.

Rapid and Highly Efficient Morphogenic Gene-Mediated Hexaploid Wheat Transformation

This paper introduces two methods for morphogenic gene-mediated wheat transformation with high efficiency and reduced tissue culture time.

Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas

This study investigates whether pregestational folate intake affects tumor latency and multiplicity in a transgenic NF1 mouse model, finding no significant differences in tumor outcomes across folate groups.

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections

This paper develops an antibody-drug conjugate targeting Pseudomonas aeruginosa that kills bacteria with minimal mammalian cell toxicity and synergizes with antibiotics.

KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine Induced Hypersensitivity, and Precipitated Withdrawal in Mice

This study evaluates KATP channel prodrugs in pain models, showing reduced hypersensitivity and opioid tolerance in mice.

Prioritizing Annotated miRNAs: Only a Small Percentage are Candidates for Biological Regulation

The paper identifies that only 2% of annotated miRNAs are likely to function as robust gene regulators based on their abundance, DROSHA dependence, and association with AGO proteins.

Semi-field and surveillance data define the natural diapause timeline for Culex pipiens across the United States

The paper uses surveillance data to define the diapause timeline for Culex pipiens across the U.S., showing population declines during diapause receptivity and highlighting genetic factors affecting population trends.

In utero exposure to morphine leads to sex-specific behavioral alterations that persist into adulthood in cross-fostered mice

This study shows that in utero morphine exposure in mice leads to sex-specific behavioral changes that persist into adulthood, with males showing more severe behavioral phenotypes and increased ethanol misuse risk.

Development of a LAG-3 Immunohistochemistry Assay for Melanoma

This paper develops a LAG-3 immunohistochemistry assay for melanoma, demonstrating high specificity, sensitivity, and reproducibility for clinical use.

Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model

This study investigates NiV Bangladesh infection in marmosets, revealing organ-specific innate and inflammatory responses through RNA-seq analysis.

CHRONIC INFLAMMATION IN ULCERATIVE COLITIS CAUSES LONG TERM CHANGES IN GOBLETCELL FUNCTION

This study shows that UC colonoids have persistent defects in mucus secretion despite reduced GC numbers, suggesting long-term epithelial dysfunction contributes to UC recurrence.

Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome.

This study investigates the impact of Giardia infection on gut microbiome structure in dogs and children, finding significant microbiome remodeling associated with infection.

Comparing rates of introgression in parasitic feather lice with differing dispersal capabilities

The paper compares introgression rates in parasitic feather lice with different dispersal abilities, finding higher genomic introgression in species with greater dispersal capabilities.

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

Multi-Locus Molecular Phylogeny of Solenopsis (Hymenoptera: Formicidae)

This study presents a multi-locus molecular phylogenetic analysis of Solenopsis ants, revealing their Neotropical origin and global spread, while highlighting issues with current taxonomy.

Obesity phenotypes are preserved in intestinal stem cell enteroids from morbidly obese patients

The paper identifies obesity-related phenotypes in intestinal stem cell enteroids from morbidly obese patients and shows they retain patient-specific traits post-bariatric surgery.

von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration

The paper identifies vwde expression as a conserved feature of blastemas involved in appendage regeneration across species and shows its functional requirement in regeneration.

Artifact-free whole-slide imaging with structured illumination microscopy and Bayesian image reconstruction

The paper presents artifact-free whole-slide imaging using structured illumination microscopy and Bayesian image reconstruction, showcasing applications in human tissue pathology.

Disrupting the leukemia niche in the central nervous system attenuates leukemia chemoresistance

This study shows that disrupting the meningeal niche reduces leukemia chemoresistance in the CNS by inhibiting leukemia-meningeal adhesion and enhancing drug efficacy.

The meninges enhance leukemia survival in cerebral spinal fluid

This study shows that meningeal interactions reduce leukemia cell death in cerebral spinal fluid, suggesting new therapeutic strategies for CNS leukemia.

Impact of Ferumoxytol Magnetic Resonance Imaging on the Rhesus Macaque Maternal-Fetal Interface

Ferumoxytol-enhanced MRI does not affect histopathology or iron levels in the maternal-fetal interface of rhesus macaques during pregnancy or up to one year post-delivery.