Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition
K. Kay, J. Lee, E. S. Hong, J. Beilis, S. Dayal, E. R. Wesley, S. Mitchell, S. Z. Wang, D. J. Silver, J. Volovetz, S. Johnson, M. McGraw, M. M. Grabowski, T. Lu, L. Freytag, , J. Lathia
This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.
bioRxiv · Nov 14, 2023Cancer Biology