Author

M. McGraw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3 Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Organism:human· 5 Organism:mouse· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

D. Bayik· 5 shared J. Lathia· 4 shared M. M. Grabowski· 4 shared A. Lauko· 3 shared D. J. Silver· 3 shared M. A. Vogelbaum· 3 shared S. Johnson· 3 shared A. Lo· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersImmunology

D. Bayik

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

K. Kay, J. Lee, E. S. Hong, J. Beilis, S. Dayal, E. R. Wesley, S. Mitchell, S. Z. Wang, D. J. Silver, J. Volovetz, S. Johnson, M. McGraw, M. M. Grabowski, T. Lu, L. Freytag, , J. Lathia

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

bioRxiv · Nov 14, 2023Cancer Biology

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

J. Lee, M. Nicosia, D. J. Silver, C. Li, D. Bayik, D. C. Watson, A. Lauko, S. Johnson, M. McGraw, M. Grabowski, D. Kish, A. Desai, W. Goodman, S. Cameron, H. Okada, , J. D. Lathia

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

bioRxiv · Aug 17, 2022 · PreprintImmunology

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

T. Alban, M. M. Grabowski, B. Otvos, D. B. Watson, A. Zalavadia, V. Makarav, K. M. Troike, M. McGraw, A. Rabljenovic, A. Lauko, C. K. A. Neumann, G. Roversi, K. Waite, G. Cioffi, N. Patil, , J. Lathia

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

bioRxiv · Mar 7, 2022 · PreprintCancer Biology

Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets

D. Bayik, C. F. Bartels, K. Lovrenert, D. Watson, D. Zhang, K. Kay, A. Lauko, S. Johnson, A. Lo, M. McGraw, M. Grabowski, A. M. Mohammadi, F. Veglia, Y. Fan, M. A. Vogelbaum, , J. Lathia

The paper identifies distinct cell adhesion signatures in glioblastoma myeloid-derived suppressor cell subsets, showing that monocytic MDSCs drive tumor growth through enhanced integrin β1 expression.

bioRxiv · Sep 27, 2021Immunology

Predicting the evolution of Lassa Virus endemic area and population at risk over the next decades

R. Klitting, L. E. Kafetzopoulou, W. Thiery, G. Dudas, S. Gryseels, A. Kotamarthi, B. Vrancken, K. Gangavarapu, M. Momoh, J. Demby Sandy, A. Goba, F. Alhasan, D. S. Grant, R. F. Garry, A. R. Smither, , S. Dellicour

The paper predicts that Lassa virus endemic areas will expand beyond West Africa due to environmental changes, increasing the population at risk from 100 million to 700 million by 2070.

bioRxiv · Sep 22, 2021Microbiology

Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins

T. Muthumalage, J. Lucas, Q. Wang, T. Lamb, M. McGraw, I. Rahman

This study investigates the pulmonary toxicity and inflammatory response of e-cigarettes containing MCT and VEA, showing they induce acute lung injury without involving SARS-CoV-2 proteins.

bioRxiv · Jun 14, 2020Pharmacology & Toxicology

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

D. Bayik, Y. Zhou, C. Park, C. Hong, D. Vail, D. J. Silver, A. J. Lauko, G. A. Roversi, D. C. Watson, A. Lo, T. J. Alban, M. McGraw, M. D. Sorensen, M. M. Grabowski, B. Otvos, , J. Lathia

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

bioRxiv · Feb 19, 2020Immunology

Chemical constituents involved in e-cigarette, or vaping product use-associated lung injury (EVALI)

T. Muthumalage, M. Friedman, M. McGraw, A. Friedman, I. Rahman

The paper identifies chemical constituents in counterfeit e-cig cartridges linked to EVALI and compares them to medical-grade and CBD cartridges.

bioRxiv · Jan 14, 2020Pharmacology & Toxicology

Global immune fingerprinting in glioblastoma reveals immune-suppression signatures associated with prognosis

T. J. Alban, A. G. Alvarado, M. D. Sorensen, D. Bayik, J. Volovetz, E. Serbinowski, E. Mulkearns-Hubert, M. Sinyuk, J. S. Hale, G. R. Onzi, M. McGraw, P. Huang, M. M. Grabowski, C. A. Wathen, T. Radivoyevitch, , J. D. Lathia

The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.

bioRxiv · May 11, 2018Cancer Biology