T. Lu

Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development

This study shows that Langerhans cells regulate postnatal dermal lymphatic development, which in turn controls adult immune responses.

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

The paper identifies FYN and KDM4 as synergistic targets for enhancing TKI efficacy in triple negative breast cancer through CRISPR screens and mechanistic analysis.

A framework for decolonising and diversifying biomedical sciences curricula: rediscovery, representation and readiness

The paper examines attitudes towards decolonising biomedical sciences curricula at the University of Bristol, finding disparities in awareness and representation among students and staff.

Antibody targeting of aging damaged isoDGR-protein doubles lifespan in a mouse model of chronic inflammation

This paper shows that targeting aging-damaged isoDGR-proteins with antibodies extends lifespan in a mouse model of chronic inflammation.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

A SHR-IDD-PIN regulatory network mediates minor vein differentiation in rice

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

PRMT5 is a therapeutic target in choroidal neovascularization

This study identifies PRMT5 as a therapeutic target for neovascular age-related macular degeneration by showing its inhibition reduces NF-κB activity and angiogenic properties in ocular endothelial cells.

Sulfane sulfur post-translationally modifies the global regulator AdpA to influence actinorhodin production and morphological differentiation of Streptomyces coelicolor

The paper identifies sulfane sulfur-mediated post-translational modification of AdpA in Streptomyces coelicolor, enhancing actinorhodin production and morphological differentiation.

Historical biogeography of early diverging termite lineages (Isoptera: Teletisoptera)

This paper reconstructs the historical biogeography of early diverging termite lineages using genetic data, finding that their distribution resulted from both over-water dispersals and land bridge migrations.

MAL suppresses OSCC tumorigenesis by maintaining epithelial cell differentiation

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

Genetic and epigenetic characteristics associated with. the rapid radiation of Aquilegia species

This study identifies genetic and epigenetic variations associated with the rapid radiation of Aquilegia species by analyzing genomes and methylomes across three lineages.

Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae

This study examines how the dual deletion of glnR and mtrA affects nitrogen metabolism gene expression in Streptomyces venezuelae, revealing GlnR's decisive role and MtrA's GlnR-dependent regulation.

Transoceanic voyages of drywood termites (Isoptera: Kalotermitidae) inferred from extant and extinct species

This study uses phylogenetic analysis to infer the transoceanic dispersal history and foraging evolution of Kalotermitidae termites, finding that dispersal and human activity shaped their global distribution.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

The Effect of a Fennel Extract on the STAT Signaling and Intestinal Barrier Function

This study shows that fennel extract improves intestinal barrier function and reduces STAT pathway activation in both in vitro and in vivo models of inflammation.

Modelling, Analysis, and Optimization of Three-Dimensional Restricted Visual Field Metric-Free Swarms

This paper develops a three-dimensional restricted visual field metric-free model to study swarm consistency and finds that optimal restricted angles improve flock cohesion compared to global visual fields.

Changes and composition of microbial community during aerobic composting of household food waste

This study compares microbial communities in natural and bacteria-added composting of household food waste, finding that different dominant bacteria influence degradation rates and odor removal.

Beige adipocytes independently improve impaired glucose metabolism in the absence of brown adipose tissues in vivo

This study shows that beige adipocytes can improve glucose metabolism and energy expenditure in the absence of brown adipose tissue in vivo.

Bacteriological Monitoring and Evaluation of Cleaning-disinfection of Computer-related Equipment in an Obstetric and Gynecology Hospital

The study evaluates bacterial contamination of computer equipment in a hospital, finding mouse pads are highly contaminated and require daily cleaning.

Recruitment of mRNAs to P granules by gelation with intrinsically-disordered proteins

The paper investigates how mRNAs are recruited into C. elegans P granules through a sequence-independent mechanism involving MEG-3, revealing similarities to stress granules.

Specification of the germline by Nanos-dependent down-regulation of the somatic synMuvB transcription factor LIN-15B

The paper shows that Nanos down-regulates LIN-15B in PGCs to reprogram their transcriptome away from oocyte/somatic fate.