Author

J. Benicky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Goldman· 4 shared A. Panigrahi· 2 shared L. Ailles· 2 shared P. Mukherjee· 2 shared R. Aljuhani· 2 shared A. M. Rozeboom· 1 shared A. Zwart· 1 shared B. Davidson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

R. Goldman

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4 papers

Recent·Most cited

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2

A. Panigrahi, J. Benicky, R. Aljuhani, P. Mukherjee, Z. Novakova, C. Barinka, R. Goldman

This study identifies LG3BP as a binding partner of Sulf-2 in HNSCC and shows that LG3BP inhibits Sulf-2 activity, reducing HNSCC cell invasion.

bioRxiv · Dec 20, 2023 · PreprintCancer Biology

Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts

P. Mukherjee, X. Zhou, J. Benicky, A. Panigrahi, R. Aljuhani, J. Liu, L. Ailles, V. H. Pomin, Z. Wang, R. Goldman

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

bioRxiv · Oct 5, 2023Cancer Biology

Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies

Y. Yang, J. Ahn, N. J. Edwards, J. Benicky, A. M. Rozeboom, B. Davidson, C. Karamboulas, K. Nixon, L. Ailles, R. Goldman

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

bioRxiv · Aug 25, 2022 · PreprintCancer Biology

PD-L1 glycosylation and its impact on binding to clinical antibodies

J. Benicky, M. Sanda, Z. Brnakova Kennedy, O. C. Grant, R. J. Woods, A. Zwart, R. Goldman

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

bioRxiv · Jul 3, 2020Cancer Biology