Author

J. C. Fowler

Primary ORCID profile (0000-0001-7546-369X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

J. C. FowleriD1 paper · Wellcome Sanger Institute

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

B. A. Hall· 2 shared M. Gerstung· 2 shared P. Jones· 2 shared R. Sood· 2 shared S. H. Ong· 2 shared A. Herms· 1 shared B. Colom· 1 shared C. King· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

B. A. Hall

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2 papers

Recent·Most cited

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

B. Colom, A. Herms, S. Dentro, C. King, R. Sood, M. Alcolea, D. Fernandez-Antoran, S. H. Ong, J. C. Fowler, K. Mahbubani, K. Saeb-Parsy, M. Gerstung, B. A. Hall, P. Jones

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

bioRxiv · Jun 25, 2021Cancer Biology

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

E. Abby, S. C. Dentro, M. W. J. Hall, J. C. Fowler, S. H. Ong, R. Sood, C. W. Siebel, M. Gerstung, B. A. Hall, P. Jones

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

bioRxiv · Jun 18, 2021 · PreprintCancer Biology