B. Colom

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

Defining the transcriptional signature of esophageal-to-skin lineage conversion

This study shows that esophageal epithelial cells can convert to hair follicle identity when exposed to skin stroma, with HIF1a inhibition blocking this transition.

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.