Author

A. Herms

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. Fernandez-Antoran· 5 shared B. Colom· 4 shared K. Murai· 4 shared P. H. Jones· 4 shared S. H. Ong· 4 shared B. A. Hall· 3 shared G. Piedrafita· 3 shared M. Gerstung· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

D. Fernandez-Antoran

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5 papers

Recent·Most cited

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

A. Herms, D. Fernandez-Antoran, M. Alcolea, A. Kalogeropoulou, U. Banerjee, G. Piedrafita, E. Abby, J. A. Valverde-Lopez, I. S. Ferreira, S. Dentro, S. H. Ong, B. Colom, K. Murai, C. King, K. T. Mahbubani, , P. H. Jones

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

bioRxiv · Jan 3, 2023Cell Biology

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

K. Murai, S. Dentro, S. H. Ong, R. Sood, D. Fernandez-Antoran, A. Herms, V. Kostiou, B. A. Hall, M. Gerstung, P. H. Jones

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

bioRxiv · Feb 3, 2022Cancer Biology

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

B. Colom, A. Herms, S. Dentro, C. King, R. Sood, M. Alcolea, D. Fernandez-Antoran, S. H. Ong, J. C. Fowler, K. Mahbubani, K. Saeb-Parsy, M. Gerstung, B. A. Hall, P. Jones

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

bioRxiv · Jun 25, 2021Cancer Biology

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

A. Herms, B. Colom, G. Piedrafita, K. Murai, S. H. Ong, D. Fernandez-Antoran, C. Bryant, C. Frezza, B. Vanhaesebroeck, P. H. Jones

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

bioRxiv · May 28, 2021Cancer Biology

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

G. Piedrafita, V. Kostiou, A. Wabik, B. Colom, D. Fernandez-Antoran, A. Herms, K. Murai, B. A. Hall, P. H. Jones

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.

bioRxiv · Jul 26, 2019Cell Biology