Author

D. Julius

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Assay:behavioral assay· 1

Frequent Co-Authors

Y. Cheng· 3 shared K. K. Touhara· 2 shared M. Brizuela· 2 shared N. D. Rossen· 2 shared S. M. Brierley· 2 shared A. Frost· 1 shared A. Hendry· 1 shared A. I. Basbaum· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

Y. Cheng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut

K. K. Touhara, N. D. Rossen, F. Deng, T. Chu, A. M. Harrington, S. Garcia Caraballo, M. Brizuela, T. O'Donnell, O. Cil, S. M. Brierley, Y. Li, D. Julius

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

bioRxiv · Feb 6, 2024Physiology

Structural basis of TRPV1 modulation by endogenous bioactive lipids

W. R. Arnold, A. S. Mancino, F. R. Moss, A. Frost, D. Julius, Y. Cheng

This study identifies a lipid-binding pocket in TRPV1 and shows that its occupancy by phosphoinositides modulates channel activity, with lipid ejection triggering activation.

bioRxiv · May 11, 2023Biochemistry

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

W. W. S. Yue, L. Yuan, J. M. Braz, A. I. Basbaum, D. Julius

This study identifies that TRPV1 drugs alter core body temperature through central projections of sensory neurons, not peripheral vascular effects.

bioRxiv · May 9, 2022 · PreprintPhysiology

Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety

J. R. Bayrer, J. Castro, A. Venkataramen, K. K. Touhara, N. D. Rossen, R. D. Morrie, A. Hendry, J. Madden, K. Braverman, G. Schober, M. Brizuela, C. Bueno Silva, H. A. Ingraham, S. M. Brierley, D. Julius

This study shows that enterochromaffin cells drive visceral pain and anxiety through serotonin signaling, with sex differences in baseline sensitivity.

bioRxiv · Apr 4, 2022 · PreprintPhysiology

Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1

J. Zhao, J. V. Lin King, Y. Cheng, D. Julius

This study identifies a two-step cysteine modification mechanism and a conserved calcium binding pocket in TRPA1 that govern its activation and calcium modulation.

bioRxiv · Dec 26, 2019Biophysics

Structural insight into TRPV5 channel function and modulation

S. Dang, M. K. van Goor, Y. Wang, D. Julius, Y. Cheng, J. van der Wijst

The paper presents cryo-EM structures of TRPV5 and its mutants, revealing structural features that explain its calcium selectivity and functional differences from other TRPV channels.

bioRxiv · Oct 4, 2018Biophysics