A. Cao

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.

The Fatty Acid Binding Protein Family Represents a Novel Target in Multiple Myeloma

This paper identifies the fatty acid binding protein (FABP) family as a novel therapeutic target in multiple myeloma, showing that FABP inhibition reduces tumor growth and alters key cellular processes.

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

The paper maps immune cell subsets in PAH lungs using MIBI-TOF, identifying mo-DCs and their role in vascular remodeling and linking immune dysregulation to disease severity in HPAH.

Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

This study identifies RGMB-AS1 as an upregulated lncRNA in PAH that modulates BMPR2 signaling and improves vascular cell function when inhibited.

E-cigarette aerosol exposure of pulmonary surfactant impairs its surface tension reducing function

This study shows that e-cigarette aerosol exposure increases the minimum surface tension of pulmonary surfactant, impairing its function and potentially contributing to lung injury.

The evolution of two transmissible leukaemias colonizing the coasts of Europe

This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.

Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus

The paper investigates the relationship between antagonism and phylogeny in Bacillus by analyzing biosynthetic gene clusters (BGCs) and finds a positive correlation between BGC distance and phylogenetic distance.

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

Evolution-inspired dissection of caspase activities enables the redesign of caspase-4 into an LPS sensing interleukin-1 converting enzyme

The paper redesigns human caspase-4 to function as a single-protein LPS sensing pathway for IL-1β cleavage, inspired by carnivore caspases, and shows cat caspase-4 exhibits similar activity.

Controlling Strawberry Mites: Comparison of New Bio-Pesticides and Conventional Chemical Pesticides

This study compares the efficacy of new bio-pesticides and conventional chemical pesticides against Tetranychus cinnabarinus, finding abamectin to be the most effective.