Kinetochores grip microtubules with directionally asymmetric strength
J. D. Larson, N. A. Heitkamp, L. E. Murray, A. R. Popchock, S. Biggins, C. L. Asbury
The paper shows that kinetochores grip microtubules six-fold stronger when pulled toward plus ends, suggesting directional asymmetry in attachment strength contributes to mitotic accuracy.
bioRxiv · Feb 22, 2024Biophysics