J. de Rutte

This study uses nanovials to screen antigen-specific T cells based on affinity and function, identifying a more specific functional TCR repertoire than standard techniques.

SEC-seq links cell secretions to transcriptomes, revealing VEGF-A secretion heterogeneity and a unique gene signature in MSCs with high secretion.

The paper introduces SEC-seq, a method to link antibody secretion with surface markers and transcriptomes in single human plasma cells, revealing pathways associated with high IgG secretion.

This paper develops a method to sort T cells based on cytokine secretion and surface markers using hydrogel nanovials, finding that polyfunctional cells are more common in CD4+ T cells and remain viable after sorting.

The paper develops a scalable method to produce hydrogel microparticles with localized surface chemistry for cell interfacing, achieving high throughput and precise shape and functionalization.

This paper introduces PicoShells to select microalgae based on biomass accumulation rates in production environments, showing an 8% faster biomass accumulation in selected Chlorella populations.

The paper introduces a heterofunctional PEG macromer for selective photopolymerization in MAP scaffolds, enhancing therapeutic delivery and 3D printing without affecting cell viability.

This paper demonstrates a method to create uniform sub-nanoliter compartments using 3D-structured microparticles, enabling stable monodisperse drops without specialized equipment.

This paper introduces a method to sort single cells based on secreted products using microparticles, enabling high-throughput screening of cell function.