Z. Mao

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

The temporal progression of immune remodeling during metastasis.

This paper uses longitudinal scRNA-seq to study immune changes in lung metastasis, identifying inflammatory programs and signaling networks associated with metastatic progression.

Defining T cell receptor repertoires using nanovial-based affinity and functional screening

This study uses nanovials to screen antigen-specific T cells based on affinity and function, identifying a more specific functional TCR repertoire than standard techniques.

Inferring membrane properties during clathrin-mediated endocytosis using machine learning

This paper uses machine learning with the Helfrich model and electron tomography data to infer biophysical properties of endocytosis membranes, revealing negative tension at early stages.

Resilient CD8+ T cells maintain a high cytotoxic capacity by balancing ROS via ME1 upregulation

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

This study identifies JM03, a crotamiton derivative, as a small molecule that extends C. elegans lifespan and improves stress resistance by inhibiting OSM-9 and activating SKN-1 signaling.

Mechanically Induced Integrin Ligation Mediates Intracellular Calcium Signaling with Single Pulsating Cavitation Bubbles

This study investigates how mechanically induced integrin ligation via cavitation bubbles triggers intracellular calcium signaling in HEK293T cells, identifying P2X channels as key mediators.

More than efficacy revealed by single-cell analysis of antiviral therapeutics

This study uses single-cell analysis to evaluate antiviral therapeutics, revealing efficacy and insights into drug resistance evolution and viral lifecycle impact.

Infection of Plasmodiophora brassicae changes the fungal endophyte community of tumourous stem mustard roots as revealed by high-throughput sequencing and culture-dependent methods

This study examines how Plasmodiophora brassicae infection alters the fungal endophyte community in stem mustard roots using sequencing and culture methods, finding reduced diversity and shifts in dominant taxa.

Dynamics of soil nematode communities revealed significant variation in greenhouse with different continuous cropping years

The paper compares soil nematode communities in greenhouses with 2 and 10 years of continuous cropping to reveal changes in community dynamics and factors influencing nematode composition.

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

This study shows that autophagy reduces lung injury by inhibiting the NF-κB pathway and inflammatory mediator release in hypoxia models.