J. Feuillard

REL deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition

This study shows REL deregulation gives AID-imprinted B-cells a competitive advantage in germinal centers, promoting expansion and potential transformation into aggressive lymphomas.

Biochemical and structural characterization of a Class A β-lactamase from Nocardia cyriacigeorgica

This study reports the biochemical characterization and high-resolution crystal structure of a class A β-lactamase from Nocardia cyriacigeorgica, revealing its structural conservation and potential for drug development.

B-cell specific expression of the murine Myd88L252P mutation correlates with the establishment of an immunosuppressive microenvironnement in Waldenstrom macroglobulinemia lymphoplasmacytic lymphoma

This study shows that B-cell specific Myd88L252P mutation in mice leads to an immunosuppressive microenvironment in Waldenstrom macroglobulinemia, promoting T-cell exhaustion and disease progression.

Increased frequencies of IgH locus suicide recombination points on Chronic Lymphocytic Leukemia with low rate of AID related somatic mutations, cMYC overexpression and short telomeres

The paper identifies a subgroup of CLL patients with increased IgH locus suicide recombination (LSR) rates, linked to low AID expression, short telomeres, and high cMYC expression, suggesting an AID-independent mechanism for LSR.

Alternative c-MYC mRNA transcripts as an additional tool for c-Myc2 and c-MycS production in BL60 tumors.

The paper identifies five c-MYC transcripts in a mouse model linked to t(8;22) translocation, associated with c-Myc2 and c-MycS production and loss of c-Myc1.

Mass cytometry and artificial intelligence define CD169 as a specific marker of SARS-CoV2-induced acute respiratory distress syndrome

The paper identifies a specific immune signature in COVID-19-associated ARDS using mass cytometry and AI, showing it differs from other ARDS causes and is linked to adverse ICU outcomes.

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

This paper demonstrates the effectiveness of splice switching oligonucleotides in knocking down c-REL and RELA expression in B cells and plasma cells, with potential therapeutic applications in B-lineage cancers.

B-cell enforced expression of the mouse ortholog of MYD88L265P is responsible for Waldenstrom-like B-cell lymphoma.

This study shows that enforced expression of MYD88L252P in B-cells leads to a lymphoplasmocytic B-cell lymphoma with a serum IgM peak in mice.

Pre-Clinical Blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma.

The paper shows that blocking PD-L1 in a mouse model of activated B-cell lymphoma leads to tumor regression, suggesting potential for PD-1/PD-L1 axis therapies combined with tyrosine kinase inhibitors.

Reproducing Transformation of Indolent B-cell Lymphoma by T-cell Immunosuppression of L.CD40 Mice.

The paper shows that T-cell immunosuppression in L.CD40 mice transforms indolent B-cell lymphoma into an aggressive form, highlighting immune surveillance's role in disease progression.