Author

J. Florence

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

D. Ansari· 2 shared G. Yi· 2 shared J. A. Bohorquez· 2 shared A. A. Al-Ghanim· 1 shared A. Abdalgelel· 1 shared A. Labani-Motlagh· 1 shared A. M. Al-Swailem· 1 shared A. Vankayalapati· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

D. Ansari

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

G. Yi, J. A. Bohorquez, S. Adduri, D. Ansari, S. John, J. Florence, O. Adejare, G. Singh, N. V. Konduru, C. Jagannath

This study develops a humanized mouse model to study HIV and tuberculosis co-infection, showing it recapitulates human immune, pathological, and metabolic responses.

bioRxiv · Mar 5, 2024Immunology

Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice

G. Yi, F. Yang, A. Labani-Motlagh, J. D. Moreira, D. Ansari, J. A. Bohorquez, S. Patel, F. Spagnolo, J. Florence, A. Vankayalapati, R. Vankayalapati, J. J. D. J. Dennehy, B. Samten

This study tests three bacteriophages against Mtb and finds that DS6A effectively kills Mtb in culture and infected macrophages, improving survival and reducing bacterial load in humanized mice.

bioRxiv · Jan 23, 2023Microbiology

Systemic mutational rescue in Escherichia coli elicited by a valency dependent, high affinity protein DNA interaction

P.J. Al-Swailem Hurd, A. M. Al-Swailem, A.A.A. Bin Dukhyil, Q.I. Sheikh, A. A. Al-Ghanim, L. Alfageih, M. Matin, Yueh Ting Lu, A. Abdalgelel, J. Florence, Mohammed Al-Shemirti, S. Al Harbi, P.E. Brown, DAVID P. HORNBY

The paper investigates how point mutations in DNA methyltransferases affect genome function and reveals a form of mutational rescue through increased valency of nucleoprotein complex formation in E. coli.

Journal of Bioinformatics and Systems Biology · Jan 1, 2023Peer-reviewedGenomics