G. Singh

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

Structural Characterization of DNA Binding Domain of Essential Mammalian Protein TTF 1

This study characterizes the DNA-binding Myb domain of TTF1 using computational modeling and experimental validation, confirming its predominantly helical structure.

circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL-positive leukemias

This study identifies circPCMTD1 as a circular RNA that promotes leukemic cell proliferation by enhancing DNA damage response tolerance through a novel peptide product.

Fdo1, Fkh1, Fkh2 and the Swi6-Mbp1 MBF complex regulate Mcd1 levels to impact eco1 rad61 cell growth in Saccharomyces cerevisiae

The paper identifies transcription factors and regulatory mechanisms that influence Mcd1 levels in eco1 rad61 yeast mutants, affecting cell growth.

Parental assigned chromosomes for cultivated cacao provides insights into genetic architecture underlying resistance to vascular streak dieback

The paper uses parentally phased genomes of Theobroma cacao to identify NLR gene clusters at QTLs associated with resistance to vascular streak dieback.

A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

This study develops a humanized mouse model to study HIV and tuberculosis co-infection, showing it recapitulates human immune, pathological, and metabolic responses.

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Chromatinization Modulates Topoisomerase II Processivity

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

Tradeoffs of increasing temperatures for the spread of antimicrobial resistance in river biofilms

This study shows that higher temperatures increase natural ARG abundance in river biofilms but accelerate the loss of invading wastewater-born ARGs.

Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection

This study compares mucosal antibody responses in individuals who received mRNA booster vaccinations or experienced breakthrough infections, finding that breakthrough infections induce stronger saliva sIgA responses than boosters.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

TGF-β Ligand Cross-Subfamily Interactions in the Response of Caenorhabditis elegans to Bacterial Pathogens

This study investigates TGF-β ligand interactions in C. elegans immune response, showing cooperative roles among ligands and distinct signaling pathway involvement.

Non-canonically regulated heterochronic expression of Hsp70 drives clonal expansion and invasion in Drosophila epithelial tumors

This study shows that non-canonical Hsp70 regulation via ROS-JNK-FOXO pathway drives clonal expansion and invasion in Drosophila epithelial tumors.

miR-17~92 Suppresses Proliferation and Invasion of Cervical Cancer Cells by Inhibiting Cell Cycle Regulator Cdt2

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.

This study develops a measles-based vaccine encoding SARS-CoV-2 spike glycoproteins that enhances neutralizing antibody responses against both omicron and historical variants.

Exposure to environmental stress decreases the resistance of river microbial communities towards invasion by antimicrobial resistant bacteria

This study investigates how environmental stress affects the invasion of antimicrobial resistant bacteria into river microbial communities, finding that stress enhances invasion success by reducing community diversity.

Consumption of the non-nutritive sweetener stevia for 12 weeks does not alter the composition of the gut microbiota

This study examines the effect of 12 weeks of stevia consumption on the gut microbiome and finds no significant changes in microbial composition or diversity.

Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin

This paper investigates catch bonding in sickle cell disease by measuring RBC adhesion dynamics to laminin under shear flow, revealing patient-specific variations in bond strength and clinical relevance.

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

Biophysical Characterization of an Essential Mammalian Protein; Transcription Termination Factor I (TTF1)

This paper characterizes the biophysical properties of a truncated TTF1 protein using multiple techniques, revealing its helical structure and molecular size.

Attenuated Dengue Virus PV001-DV Induces Oncolytic Cell Death and Potent Anti-Tumor Immunity

This study shows that PV001-DV, an attenuated Dengue virus, induces oncolytic cell death and activates anti-tumor immunity in melanoma and breast cancer cells.

Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain mediated tumors in Drosophila

This study shows that constitutive heat shock proteins, not stress-inducible Hsp70, are essential for tumor growth in Drosophila, independent of HSF regulation.

CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

Population Dynamics of Hybrid State during Adaptive Therapy in Cancer

The paper develops a Lotka-Volterra model to study population dynamics of drug-sensitive, resistant, and hybrid states in cancer during adaptive therapy, identifying key parameters affecting treatment effectiveness.