G. Yi

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

This study develops a humanized mouse model to study HIV and tuberculosis co-infection, showing it recapitulates human immune, pathological, and metabolic responses.

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents

This paper develops a human URAT1 transgenic mouse model to evaluate urate-lowering agents and study URAT1-related pathogenesis in gout.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

HIV-differentiated metabolite N-Acetyl-L-Alanine dysregulates human natural killer cell responses to Mycobacterium tuberculosis infection

The paper identifies N-Acetyl-L-Alanine as a metabolite dysregulated by HIV that inhibits NK cell responses to Mycobacterium tuberculosis infection.

Development of a human glioblastoma model using humanized DRAG mice for immunotherapy

This study develops a humanized DRAG mouse model to test GBM immunotherapy, showing anti-PD-1 antibodies reduce immunosuppressive cells in xenografted tumors.

Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice

This study tests three bacteriophages against Mtb and finds that DS6A effectively kills Mtb in culture and infected macrophages, improving survival and reducing bacterial load in humanized mice.

Rotavirus NSP1 subverts the antiviral OAS-RNase L pathway by inducing RNase L degradation

This study identifies a novel mechanism by which rotavirus NSP1 subverts the OAS-RNase L antiviral pathway by inducing RNase L degradation through ubiquitination.

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Genetic characterization of stem cell-like cancer cell in the peri-tumoral regions and proliferative lymphocyte in the peripheral blood of patients with glioblastoma

This study identifies stem cell-like GBM cells outside the contrast-enhancing region and proliferative lymphocytes in GBM patients' blood, linking them to recurrence and immunotherapy.

Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

This study develops tunable self-cleaving ribozymes to modulate gene expression in eukaryotic systems, showing effectiveness in mammalian cells and Drosophila embryos.

Ginsenoside Rg1 defenses PC-12 cells against hydrogen peroxide-caused damage via up-regulation of miR-216a-5p

This study shows that ginsenoside Rg1 protects PC-12 cells from hydrogen peroxide damage by up-regulating miR-216a-5p, which reduces apoptosis and autophagy.

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.