S. John

A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

This study develops a humanized mouse model to study HIV and tuberculosis co-infection, showing it recapitulates human immune, pathological, and metabolic responses.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-cadherin

This study shows that FYN phosphorylates VE-cadherin in Schlemm's canal endothelial cells, increasing AJ permeability and reducing aqueous humor outflow resistance under elevated IOP.

Glucose intolerance induces anxiety-like behaviors independent of obesity and insulin resistance in a novel model of nutritional metabolic stress

This study shows glucose intolerance can cause anxiety-like behaviors without obesity or insulin resistance, using a new nutritional model of metabolic stress.

Inference of host-pathogen interaction matrices from genome-wide polymorphism data

This paper develops a Bayesian method to infer host-pathogen interaction matrices from genome-wide polymorphism data and applies it to HCV-infected humans to identify new resistance genes and GxG interactions.

The role of Kölliker-Fuse nucleus in breathing variability

This study uses computational models to explore KF activity dynamics and their role in normal breathing and Rett syndrome-like respiratory patterns.

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

This paper introduces an electrocatalytic system for on-site oxygen production to support cell therapies under hypoxic conditions.

Zoledronic acid improves bone quality and muscle function in a high bone turnover state

This study shows zoledronic acid improves bone quality and muscle function in a mouse model of metabolic bone disease by reducing TGFβ release from bone.

Cardiac Effects of a Novel pH-Insensitive Sodium-Calcium Exchanger Mouse

This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.

Nitrogen fixation in mesoscale eddies of the North Pacific Subtropical Gyre: patterns and mechanisms

The paper investigates elevated nitrogen fixation rates in mesoscale eddies of the North Pacific Subtropical Gyre, finding that anticyclones support higher diazotroph abundances due to phosphate limitation relief, while physical dynamics influence other taxa.

HIV-differentiated metabolite N-Acetyl-L-Alanine dysregulates human natural killer cell responses to Mycobacterium tuberculosis infection

The paper identifies N-Acetyl-L-Alanine as a metabolite dysregulated by HIV that inhibits NK cell responses to Mycobacterium tuberculosis infection.

Transcription factor HSFA7b controls ethylene signaling and meristem maintenance at the shoot apical meristem during thermomemory

This study identifies HSFA7b as a transcription factor that regulates ethylene signaling and SAM maintenance during thermomemory in Arabidopsis.

Cross-Species association statistics for genome-wide studies of host and parasite polymorphism data

This study develops and evaluates statistical indices to identify coevolving loci between hosts and parasites using cross-species genome-wide association analyses.

Functional Aspects of the Eustachian Tube by Means of 3D-Modeling

This study creates a 3D model of the Eustachian tube using histology to better understand its anatomy and biomechanics, aiding in diagnostic and interventional tool development.

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

Preliminary Minimum Reporting Requirements for Reporting In-Vivo Neural Interface Research: I. Implantable Neural Interfaces

This paper outlines preliminary reporting guidelines for implantable neural interface research developed by IEEE WG P2794 to improve transparency, reproducibility, and integration of neurotechnologies.

Human marginal zone B cell development from early T2 progenitors

The paper identifies an IgMhi developmental trajectory in human B cell maturation that connects T2 progenitors to marginal zone B cells and links its disruption to severe SLE.

STIL a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancer

This study identifies STIL as an oncogene in colorectal cancer that promotes stemness and drug resistance through Shh-independent mechanisms involving β-catenin and p-AKT.

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

Neutral genomic signatures of host-parasite coevolution.

The paper models host-parasite coevolution and shows that parasite population size changes can be detected in neutral polymorphism data, while host changes cannot due to differing mutation and drift dynamics.

Resident Macrophages are Locally Programmed for Silent Clearance of Apoptotic Cells

The paper identifies macrophages that silently clear apoptotic cells by expressing AC receptors and limiting nucleic acid responses, showing that tissue cues program this behavior.