An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes
S. Caielli, P. Balasubramanian, J. Rodriguez-Alcazar, U. Balaji, Z. Wan, J. Baisch, C. Smitherman, L. Walters, P. Sparagana, D. Nehar-Belaid, R. Marches, L. Nassi, K. Stewart, J. Fuller, J. F. Banchereau, , V. Pascual
The paper identifies an unconventional IL-1β secretion mechanism in lupus monocytes requiring Type I IFN, involving mitochondrial RNA and the NLRP3 inflammasome.
bioRxiv · Aug 3, 2023 · PreprintImmunology