T. Lewis

A Multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A.

This study uses multiscale techniques to reveal the molecular structure of autoinhibited KIF5A, showing how its C-terminal tail contributes to autoinhibition and how mutations affect this state.

Clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus (HPAIV) from the 2021/22 epizootic is highly duck adapted and poorly adapted to chickens

This study investigates the virulence and transmission of H5N1 HPAIV in ducks and chickens, finding it highly infectious in ducks but poorly adapted to chickens.

High pathogenicity avian influenza (H5N1) in Northern Gannets: Global spread, clinical signs, and demographic consequences

This study tracks the global spread of HPAI H5N1 in Northern Gannets, documenting high mortality rates and demographic impacts across multiple colonies.

The role of airborne particles in the epidemiology of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in commercial poultry production units

The paper investigates airborne transmission of clade 2.3.4.4b H5N1 HPAIV in poultry units, finding that infectious virus can travel short distances but not between premises, suggesting biosecurity measures are more critical.

Genetic architecture and evolution of color variation in American black bears

This study identifies a missense mutation in TYRP1 responsible for the cinnamon color morph in American black bears and traces its evolutionary origin and spread.

Steric-free bioorthogonal profiling of cellular acetylation and glycosylation via a fluorine-selenol displacement reaction (FSeDR)

This paper introduces a fluorine-selenol displacement reaction (FSeDR) to label and image acetylation and glycosylation, and uses it with SILAC proteomics to profile acetylation substrates in prostate cancer cells.

COVID-19 and the abrupt shift to remote learning: Impact on grades and perceived learning for undergraduate biology students

This study examines the impact of the shift to remote learning during the COVID-19 pandemic on undergraduate biology students' grades and perceptions, finding no disproportionate negative effects on marginalized groups but highlighting negative impacts on learning experiences.

Decadal changes in fire frequencies shift tree communities and functional traits

This study shows that long-term changes in fire frequency alter tree communities and functional traits across different ecosystems.

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.