J. W. Brown

This study identifies IFRD1 as a key regulator of ER stress and urothelial homeostasis in mice, showing its role in maintaining bladder function and preventing cell shedding.

The paper develops analogs of SGC-CK2-1 to improve pharmacokinetic properties in mice by inhibiting GST and P450 enzymes through co-dosing protocols.

This study identifies a temperature-sensitive splicing switch in the REVEILLE2 gene that integrates nocturnal temperature changes with the circadian clock in Arabidopsis.

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

The paper develops BaRTv2.18, a highly resolved barley reference transcriptome, improving transcript diversity and quantification accuracy over previous versions.

This paper introduces a new Arabidopsis transcriptome dataset with improved accuracy and resolution using novel Iso-seq analysis methods, enhancing transcript expression and splicing analysis.

This study identifies 3-Sulfo-Lewis A as the epitope recognized by the antibody Das-1, which is reexpressed in metaplastic and carcinomatous gastrointestinal lesions.

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.

This study evaluates how tree priors and molecular clocks affect diversification rate estimates in Bayesian phylogenetics, finding minimal impact when data are informative and substitution rates are low-to-moderate.

The paper identifies outlier genes causing conflict between supermatrix and coalescent-based species trees in two datasets and proposes a framework for examining alternative edges in phylogenomic analyses.

The paper introduces a method to improve divergence-time estimation by filtering genes from phylogenomic datasets based on clock-likeness and topological compatibility, showing it reduces error in time inference.

The paper investigates how prior assumptions in divergence time estimation can lead to inaccurate age estimates for angiosperms, even without data, highlighting issues with calibration densities and prior distributions.

The paper introduces Quartet Sampling (QS), a method to distinguish conflicting support from poor support in plant phylogenies, showing it effectively identifies discordant evolutionary relationships.

The paper maps whole genome duplications (WGDs) and diversification shifts in Caryophyllales, finding some correlations but no tight link between WGDs and diversification rates.

The paper critiques Puttick et al.'s conclusion that Bayesian methods are superior for phylogenetic reconstruction from morphological traits, arguing that their comparison was flawed and that ML and Bayesian methods are concordant when uncertainty is properly considered.