Cancer BiologybioRxivPreprint
Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP
G. Kuser Abali, F. Noguchi, P. Szeto…·M. Shackleton
This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.
DOI 10.1101/2021.11.02.467024