Author

M. Shackleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P. Szeto· 5 shared N. C. Wong· 4 shared P. Zhao· 4 shared Y. Zhang· 4 shared G. Kuser Abali· 3 shared M. Ameratunga· 3 shared M. Andrews· 3 shared C. Huang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

P. Szeto

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Computational repurposing of oncology drugs through off-target drug binding interactions from pharmacological databases

I. R. Walpole, F. Y. Zaman, P. Zhao, V. M. Marshall, F. P. Lin, D. M. Thomas, M. Shackleton, A. A. Antolin, M. Ameratunga

This paper presents a computational method to identify off-target drug binding interactions for oncology drug repurposing using pharmacological databases and clinical data.

bioRxiv · Jul 1, 2023Biochemistry

Prospective isolation according to melanin pigment content of melanoma cells with heterogeneous potentials for disease propagation

C. Fedele, G. Kuser Abali, R. Rossi, P. Zhao, J. Li, P. Szeto, Y. Zhang, N. C. Wong, M. Andrews, M. Shackleton

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

bioRxiv · Oct 31, 2022Cancer Biology

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP

G. Kuser Abali, F. Noguchi, P. Szeto, Y. Zhang, C. Huang, C. K. Barlow, G. Pomilio, C. Chew, S. Masoumi Moghaddam, P. Zhao, M. Andrews, I. Leece, J. G. Cheung, M. Ameratunga, N. C. Wong, , M. Shackleton

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology

EZH2 Abundance Regulated by UHRF1/UBE2L6/UBR4 Ubiquitin System is the Potential Therapeutic Target to Trigger Pigmented Phenotype in Melanoma

G. Kuser Abali, Y. Zhang, P. Szeto, P. Zhao, S. Masoumi Moghaddam, I. Leece, C. Huang, J. Cheung, M. Ameratunga, F. Noguchi, M. Andrews, N. C. Wong, R. B. Schittenhelm, M. Shackleton

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

bioRxiv · Mar 4, 2021 · PreprintCancer Biology

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

X. Zhang, L. Yang, P. Szeto, Y. Zhang, K. Amarasinghe, J. Li, C. McLean, M. Shackleton, K. Harvey

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.

Oncogene · Jun 19, 2020Peer-reviewedCancer Biology

A peptide-signal amplification strategy for the detection and validation of neoepitope presentation on cancer biopsies

S. H. Ramarathinam, P. Faridi, A. Peng, P. Szeto, N. C. Wong, A. Behren, M. Shackleton, A. W. Purcell

The paper develops a mass spectrometry-based method to detect HLA-bound peptides from tumor biopsies, enabling the identification of neoepitopes from as few as 1000 cells or 1 mg of tissue.

bioRxiv · Jun 12, 2020 · PreprintImmunology