Author

J. Gruber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Barardo· 2 shared L. F. Ng· 2 shared A. Bittner· 1 shared A. Li· 1 shared A. M. Li· 1 shared A. van Dieren· 1 shared A. Zupanic· 1 shared B. Chiu· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPhysiology

D. Barardo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Stress Knowledge Map: A knowledge graph resource for systems biology analysis of plant stress responses

C. Bleker, Z. Ramsak, A. Bittner, V. Podpecan, M. Zagorscak, B. Wurzinger, S. Baebler, M. Petek, M. Kriznik, A. van Dieren, J. Gruber, L. Afjehi-Sadat, A. Zupanic, M. Teige, U. C. Vothknecht, K. Gruden

The paper introduces Stress Knowledge Map, a resource with two knowledge graphs for plant stress responses, and demonstrates its use in hypothesis generation and analysis.

bioRxiv · Nov 28, 2023Plant Biology

The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience

K. K. Pabis, D. Barardo, J. Gruber, O. Sirbu, K. Selvarajoo, M. Kaeberlein, B. K. Kennedy

The paper reanalyzes lifespan studies and finds that short-lived controls overestimate intervention efficacy, proposing a 900-day rule to assess confidence in longevity interventions.

bioRxiv · Oct 8, 2023 · PreprintPhysiology

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

H. Jiang, R. L. Greathouse, B. He, Y. Li, A. M. Li, B. Forgo, M. Yip, A. Li, M. Shih, S. Banuelos, M. Zhou, J. Gruber, H. Shimada, B. Chiu, J. Ye

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

bioRxiv · Sep 5, 2021 · PreprintCancer Biology

Inhibition of mTOR decreases insoluble protein burden by reducing translation in C. elegans

Z. Yee, S. H. Y. Lim, L. F. Ng, J. Gruber

This study shows that inhibiting mTOR reduces insoluble protein accumulation and extends lifespan in C. elegans by decreasing translation.

bioRxiv · Aug 17, 2020Biochemistry

Doubling healthy lifespan using drug synergies

T. Dessale, K. C. Batchu, D. Barardo, L. F. Ng, V. Y. M. Lam, L. Xiao, M. R. Wenk, N. S. Tolwinski, J. Gruber

This paper shows that combining drugs targeting multiple ageing pathways in C. elegans can double lifespan and improve healthspan, with potential for human applications.

bioRxiv · Aug 1, 2017Biochemistry