Undruggable oncoproteins cMyc and NMyc bind to mediator of transcription with superior high affinity
A. Knight, J. Houser, T. Otasevic, V. Juran, V. Vybihal, M. Smrcka, D. martin
The paper identifies a conserved 9aaTAD region in c-Myc and N-Myc that binds the KIX domain with high affinity, suggesting a potential druggable target for MYC-driven tumors.
bioRxiv · Mar 15, 2024 · PreprintBiochemistry