Author

D. E. Clapham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Assay:cryo-EM· 3 Organism:mouse· 3 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:electrophysiology· 1

Frequent Co-Authors

J. Duan· 2 shared J. Zhang· 2 shared P. R. Houlihan· 2 shared S. E. Brauchi· 2 shared S. Sanchez-Martinez· 2 shared S.-H. Sheu· 2 shared Z. Li· 2 shared A. L. Lemire· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

J. Duan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

A. N. Miller, P. R. Houlihan, E. Matamala, D. Cabezas-Bratesco, G. Y. Lee, B. Cristofori-Armstrong, T. L. Dilan, S. Sanchez-Martinez, D. Matthies, R. Yan, Z. Yu, D. Ren, S. E. Brauchi, D. E. Clapham

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

bioRxiv · Sep 2, 2022Biophysics

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

S.-H. Sheu, S. Upadhyayula, V. Dupuy, S. Pang, A. L. Lemire, D. Walpita, H. A. Pasolli, F. Deng, J. Wan, L. Wang, J. Houser, S. Sanchez-Martinez, S. E. Brauchi, S. Banala, M. Freeman, , D. E. Clapham

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

bioRxiv · Sep 27, 2021Cell Biology

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc

S. Gao, W. C. Valinsky, N. C. On, P. R. Houlihan, Q. Qu, L. Liu, P. Xiaojing, D. E. Clapham, N. Yan

The paper presents cryo-EM structures of NaChBac in nanodiscs and its complex with HuwenToxin IV, revealing toxin docking details and enabling studies of GMTs on Nav channels.

bioRxiv · Apr 16, 2020Biophysics

Cryo-EM structure of the polycystin 2-l1 ion channel

R. E. Hulse, Z. Li, R. K. Huang, J. Zhang, D. E. Clapham

The paper reports the near-atomic structure of the polycystin 2-l1 ion channel at 3.1 Å resolution, revealing structural differences from polycystin-2 that correlate with distinct ion permeability.

bioRxiv · Mar 22, 2018Biophysics

Structure of the mouse TRPC4 ion channel

J. Duan, J. Li, Z. Bo, G.-L. Chen, X. Peng, Y. Zhang, J. Wang, D. E. Clapham, Z. Li, J. Zhang

This study presents the cryo-EM structure of the mouse TRPC4 ion channel, revealing unique features that contribute to its ion selectivity and evolutionary diversity within the TRP family.

bioRxiv · Mar 15, 2018Biophysics

PKD2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

X. Liu, T. Vien, J. Duan, S.-H. Sheu, P. G. DeCaen, D. E. Clapham

The paper identifies PKD2 as a functional ion channel subunit in primary cilia of renal collecting duct epithelial cells, showing it conducts potassium and sodium but little calcium and is sensitized by high cilioplasmic [Ca2+].

bioRxiv · Nov 7, 2017Biophysics