S. Pang

Structure, interaction, and nervous connectivity of beta cell primary cilia

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

An acute microglial metabolic response controls metabolism and improves memory

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans.

This study shows that reduced FAD levels due to impaired mitochondrial proline catabolism in C. elegans males leads to sperm dysfunction and reduced reproductive fitness, which can be reversed by restoring FAD levels.

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

Computational modeling reveals a hydrophobic force-induced pore-forming mechanism for cholesterol-dependent cytolysins

The paper uses computational modeling to reveal a hydrophobic force-induced mechanism for pore formation in cholesterol-dependent cytolysins.

Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

Genomic and epidemiological evidence of a dominant Panton-Valentine leucocidin-positive Methicillin Resistant Staphylococcus aureus lineage in Sri Lanka with spread to the United Kingdom and Australia

The paper conducts genomic analysis of MRSA in Sri Lanka, identifying a dominant PVL-positive ST5-MRSA-IVc lineage that spreads internationally.

The Evolutionary Landscape of Pan-Cancer Drives Clinical Aggression

This study identifies four pan-cancer evolutionary patterns linked to clinical aggressivity using Bayesian mutation landscape analysis across 21 cancer types.