ImmunologybioRxivPreprint
Disruption of Z-RNA-binding of ADAR1 induces Aicardi-Goutieres syndrome-like encephalopathy in mice
T. Nakahama, Y. Kato, T. Shibuya…·Y. Kawahara
This study shows that disrupting ADAR1 p150's Z-RNA-binding domain in mice causes AGS-like encephalopathy with type I IFN signature, which is alleviated by MDA5 deletion.
DOI 10.1101/2020.12.16.422984