MicrobiologybioRxiv
HIV-1 vaccine design through minimizing envelope metastability
L. He, S. Kumar, J. J. Allen…·J. Zhu
This paper demonstrates that gp41ECTO is the main source of HIV-1 envelope metastability and shows that stabilizing it improves nanoparticle assembly and induces more effective tier 2 neutralizing antibodies.
DOI 10.1126/sciadv.aau6769