ImmunologybioRxiv
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease
G. Liu, J.-H. Lee, Z. M. Parker…·M. U. Gack
This study shows ISG15 is essential for MDA5-mediated antiviral responses and is counteracted by SARS-CoV-2's PLpro protease.
DOI 10.1038/s41564-021-00884-1