Author

C. Chiang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Zheng· 2 shared J. Zeng· 2 shared M. Zhang· 2 shared T. Xiao· 2 shared C. Chen· 1 shared C. Zhong· 1 shared D. Acharya· 1 shared D. Pan· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. Zheng

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

C. Chiang, M. Zhang, J. Huang, J. Zeng, C. Chen, D. Pan, H. Yang, M. Yang, Q. Han, W. Zou, T. Xiao, Y. Zou, F. Yin, Z. Li, L. Zhu, D. Zheng

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

bioRxiv · Jun 27, 2022Pharmacology & Toxicology

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

C. Chiang, T. Xiao, S. Fan, H. Zheng, S. Li, W. Guo, M. Zhang, C. Zhong, J. Zeng, D. Zheng

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

bioRxiv · Feb 10, 2021 · PreprintCancer Biology

ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

G. Liu, J.-H. Lee, Z. M. Parker, D. Acharya, J. J. Chiang, M. van Gent, W. Riedl, M. E. Davis-Gardner, E. Wies, C. Chiang, M. U. Gack

This study shows ISG15 is essential for MDA5-mediated antiviral responses and is counteracted by SARS-CoV-2's PLpro protease.

bioRxiv · Oct 26, 2020Immunology