J.-H. Lee

Mosaic display of stable hemagglutinin monomers induces broad immune responses

This study develops a nanoparticle vaccine displaying conserved influenza HA epitopes, inducing broad neutralizing antibodies against multiple viral subtypes.

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

Disease-associated astrocyte epigenetic memory promotes CNS pathology

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.

Development of robust antiviral assays using relevant apical-out human airway organoids

This paper develops AORBs, a high-throughput human airway organoid system, to robustly assess antiviral efficacy against SARS-CoV-2 with high throughput and clinical relevance.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition

This study uses cryo-EM to determine multiple high-resolution structures of human MutSβ, revealing conformational changes linked to ATP/ADP binding and DNA recognition.

mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

This study identifies Daam1/2 as a regulator of Wnt signaling that is essential for Paneth cell differentiation and intestinal stem cell homeostasis.

MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria

This study identifies MARCH5-dependent NLRP3 ubiquitination as essential for NEK7 mitochondrial docking during inflammasome assembly.

Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

Extended longevity geometrically-inverted proximal tubule organoids for protein uptake studies

This study develops geometrically-inverted proximal tubule organoids to better model proteinuric kidney disease by enabling apical surface access for protein uptake studies.

Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

A new protocol for speed vernalisation of winter cereals

This paper introduces a new vernalisation protocol that significantly reduces generation time for winter cereals by combining extended photoperiod and low-temperature exposure with speed breeding conditions.

Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency

This study investigates the thermal behavior of FGF21 and designs a variant with enhanced therapeutic potency through structural analysis and mutagenesis.

Mutual Regulation between PFKP and VEGF Promotes Glioblastoma Tumor Growth

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

Development of a machine learning model to estimate biotic ligand model-based predicted no-effect concentrations for copper in freshwater

The paper develops DNN models to estimate BLM-based PNECs for copper in freshwater using different input variables, showing improved predictive performance compared to existing tools.

Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

The paper identifies an IL-1β-Notch-Fosl2 axis that regulates differentiation plasticity of airway progenitors during alveolar regeneration.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

This study identifies Kasugamycin as a novel CHIT1 inhibitor with strong antifibrotic effects in pulmonary fibrosis models.

TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells

The paper identifies TPX2 amplification in late-passaged hESCs as a driver of mitotic aberrations through transcriptome and genomic analysis.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

Bioassemblying Macro-Scale, Lumnized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion

This paper introduces MOrPF, a method to assemble airway organoids into scaffold-free, shape-defined tubes, demonstrating shape stability and epithelial characteristics.

ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

This study shows ISG15 is essential for MDA5-mediated antiviral responses and is counteracted by SARS-CoV-2's PLpro protease.

Protein hyperacylation links mitochondrial dysfunction with nuclear organization

This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

Reconstitution of Alveolar Regeneration via novel DATPs by Inflammatory Niches

The paper identifies DATPs as a novel progenitor population in alveolar regeneration and shows how IL-1β-mediated inflammation impairs their differentiation into mature AT1 cells.

Molecular mapping of qBK1Z, a major QTL for bakanae disease resistance in rice

This study identifies a major QTL, qBK1Z, for bakanae disease resistance in rice using QTL mapping in recombinant inbred lines derived from a resistant and susceptible variety.

Differential RNA editing between epithelial and mesenchymal tumors impacts mRNA abundance in immune response pathways

The paper identifies differential RNA editing between epithelial and mesenchymal tumors and shows its impact on immune response pathways through ILF3-mediated transcript stabilization.

Undinarchaeota illuminate the evolution of DPANN archaea

The paper reconstructs genomes of Undinarchaeota, a new DPANN archaeal lineage, and analyzes their phylogenetic placement and potential gene exchange with hosts.

Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.