J. J. Saucerman

This paper uses a computational model to screen FDA-approved drugs for their ability to inhibit cardiomyocyte hypertrophy, identifying midostaurin as a context-dependent inhibitor.

The paper integrates transcriptomics and metabolomics data with a heart metabolic model to identify metabolic adaptations during cardiotoxicity from three compounds.

This study shows that Ror1/2 receptors are essential for cardiac myofibroblast differentiation and heart remodeling in response to pressure overload.

This study develops a multiscale model of maternal heart growth during pregnancy, showing that progesterone levels in early gestation significantly contribute to cardiac growth.

The paper investigates how mechanical stretch and biochemical agonists interact to regulate matrix metalloproteinase secretion by cardiac fibroblasts, revealing synergistic and antagonistic effects on protease expression.