Author

C. Lengner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

N. Li· 2 shared Z. Yu· 2 shared A. Deneka· 1 shared A. Merrell· 1 shared B. Andersen· 1 shared B. Stanger· 1 shared B. W. Katona· 1 shared C. F. Guerrero-Juarez· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

N. Li

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

I. Bychkov, A. Deneka, I. Topchu, R. P. Pangeni, C. Lengner, J. Karanicolas, E. A. Golemis, P. Makhov, Y. Boumber

This study shows MSI2 promotes lung tumorigenesis by enhancing ATM expression and DNA damage response, suggesting MSI2 as a potential therapeutic target in lung cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Y. Tian, X. Wang, Z. Cramer, J. Rhoades, K. N. Estep, X. Ma, S. A. Tzivelekidis, B. W. Katona, F. B. Johnson, Z. Yu, M. A. Blanco, C. Lengner, N. Li

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

bioRxiv · Jul 26, 2022 · PreprintCancer Biology

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

Y. Sela, J. Li, P. Kuri, A. Merrell, N. Li, C. Lengner, P. Rompolas, B. Stanger

This paper introduces PIC-IT, a photoconversion-based technique to isolate spatially distinct tumor cells, revealing phenotypic heterogeneity and NF-κB/AP-1 signaling enrichment in disseminated tumor cells.

bioRxiv · Oct 5, 2020Cancer Biology

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

X. Sheng, Z. Lin, C. Lv, C. Shao, X. Bi, M. Deng, J. Xu, C. F. Guerrero-Juarez, M. Li, X. Wu, R. Zhao, X. Liu, Q. Wang, Q. Nie, W. Cui, , Z. Yu

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

bioRxiv · Oct 21, 2019 · PreprintCell Biology